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Fourth
Semester Pokhara University B.Sc. Biochemistry (Revised Syllabus) Chem
221 Quantum Chemistry, Molecular Spectroscopy
and Group Theory )
Section IThe Motivation for Quantum Mechanics: The ultraviolet catastrophe, The Photoelectric effect, Quantization of Electronic angular momentum, Wave particle duality. The Schrodinger Equation: The time independent Schrodinger equation. Postulates of quantum mechanics, Particle in a one Dimensional Box, Particle in a three – dimensional Box Section IIHarmonic Oscillator, Rigid Rotor, Angular Momentum, hydrogen like atom, Eigen function and probabilities functions for hydrogen like atoms, Orbital angular momentum of the hydrogen like atom Section IIIMolecular Spectroscopy of diatomic molecules: Rotational and Raman spectra of rigid and non rigid molecules, vibrational and Raman vibrational spectra of harmonic and anharmonic molecules, Rotation - vibration and Raman Rotation - vibration spectra Section IVGroup Theory :Symmetry operations and elements, Group’, Method of classifying groups (point groups), Martix Representation, reducible representation, irreducible representation , Construction of Character table and its properties. Text Book:1. “Physical Chemistry” Alberty and Silbey. 2.A
Brief Review of Elementary Quantum Chemistry
C.
David Sherrill http://vergil.chemistry.gatech.edu/notes/quantrev/quantrev.html 3.A primer to Group Theory for Chemists Vishwanath P. Agrawal
Section I The Metabolism of Glycogen in Animals: Regulation
of Metabolic Pathways, Coordinated Regulation of Glycolysis and Gluconeogenesis,
Coordinated Regulation of Glycogen Synthesis and Breakdown, Analysis of Metabolic
Control Section II Glycolysis, Gluconeogenesis and the Pentose Phosphate Pathway: Glycolysis, Feeder pathways for glycolysis, Fates of pyruvate under anaerobic conditions; Gluconeogenesis, Pentose Phosphate Pathway of glucose oxidation. Section III The citric acid cycle: Production of acetyl CoA, Reactions of the Citric Acid Cycle, Regulation of citric acid cycle. The glyoxylate cycle. Section IV Oxidative Phosphorylation: Oxidative Phosporylation,
Electron-Transfer Reactions in Mitochondria, ATP Synthesis, Regulation of Oxidative
Phosphorylation, Mitochondrial Genes: Their Origin and the Effects of Mutations,
The Role of Mitochondria in Apoptosis and Oxidative Stress Bioenergetics and Metabolism I (Biochem 222): For 2005 Batch Section I Principles of Bioenergetics: Bioenergetics and Thermodynamics, Phosphoryl Group Transfers and ATP, Biological Oxidation-Reduction Reactions The Metabolism of Glycogen in Animals: Regulation
of Metabolic Pathways, Coordinated Regulation of Glycolysis and Gluconeogenesis,
Coordinated Regulation of Glycogen Synthesis and Breakdown, Analysis of Metabolic
Control Section II Glycolysis, Gluconeogenesis and the Pentose Phosphate Pathway: Glycolysis, Feeder pathways for glycolysis, Fates of pyruvate under anaerobic conditions; Gluconeogenesis, Pentose Phosphate Pathway of glucose oxidation. Section III The citric acid cycle: Production of acetyl CoA, Reactions of the Citric Acid Cycle, Regulation of citric acid cycle. The glyoxylate cycle. Section IV Oxidative Phosphorylation: Oxidative Phosporylation,
Electron-Transfer Reactions in Mitochondria, ATP Synthesis, Regulation of Oxidative
Phosphorylation, Mitochondrial Genes: Their Origin and the Effects of Mutations,
The Role of Mitochondria in Apoptosis and Oxidative Stress Text book: Nelson DL and Cox MM (2003) Lehninger Principles of biochemistry, 4 th Edition, WH Freeman and Company, New York .
Section I Genes and Chromosomes: Chromosomal Elements, DNA Supercoiling, The Structure of Chromosomes
Section II DNA Metabolism: DNA Replication, DNA Repair, DNA Recombination
Section III RNA Metabolism: DNA dependent synthesis of RNA, RNA processing, RNA dependent synthesis of RNA and DNA
Section IV Protein metabolism: Genetic code, Protein Synthesis, Protein targeting and degradation Regulation
of Gene expression: Principles of Gene regulation
Biochem
223 ( Molecular Biology)
Genes
and Chromosomes and DNA metabolism: Section II RNA metabolism: DNA dependent synthesis of RNA, RNA processing, RNA dependent synthesis of RNA and DNA Section III Protein metabolism: Genetic code, Protein Synthesis, Protein targeting and degradation Section IV Regulation of Gene expression: Principles of Gene regulation, Regulation of gene expression in prokaryotes, Regulation of gene expression in eukaryotes
Text book: ” Lehninger Principles of biochemistry” Nelson and Cox.4th edition.Macmillion Worth Publisher.
Biol
224 ( Human Biology) (i) General Introduction. Importance
of Human Biology. Terminology of
anatomical and Physiological terms. Section II
(i)
Digestive System: Digestive organs and physiology of digestion. Section III
(i) Circulatory System: Structure
and function of heart. Arterial and
venous system in brief. Section IV
(i)
Endocrine glands Text Book : Erelyn Pearce Anatomy and Physiology for Nurses
Section
I Overview of
bioinformatics: The scope of bioinformatics, Bioinformatics and the
Internet, Useful bioinformatics sites
on the WWW Retrieval of
biological data: Data retrieval with Entrez and DBGET/ LinkDB, Data
retrieval with SRS (sequence retrieval system) Section III Multiple sequence
alignment: gene and protein families: multiple sequence alignment and family
relationships, Protein families and pattern databases, Protein domain families Section IV Structural bioinformatics : Conceptual models of protein structure , the relationship of protein three-mdimensional structure to protein function, The evolution of protein structure and function , obtaining, viewing and analyzing structural data, structural alignment, classification of proteins of known three- dimensional structure: CATH and SCOP , introduction to protein structure prediction , structure prediction by comparative modeling, Secondary structure prediction , Advanced protein structure prediction and prediction stratages Text book: Westhead, Parish and Twyman “ Bioinformatics” Viva
Books Pvt. Ltd.(Ist Ed. –2003)
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